Ergothioneine (EGT) is a unique amino acid derivative with vitamin-like properties found mainly in specific foods such as mushrooms, red and black beans. Ergothioneine has superior antioxidant capacity, and oxidative stress has been linked to various diseases and the aging process. Interest in EGT is growing due to its vast therapeutic potential in supporting health and longevity.
The human body is able to synthesise ergothioneine on its own, but the amount synthesised is very limited and falls far short of what our bodies need. Moreover, the body's ability to synthesise ergothioneine decreases with age. Therefore, it is necessary to supplement ergothioneine through exogenous sources.
As an adaptogen antioxidant, ergothioneine preferentially accumulates in cells and tissues exposed to oxidative stress and damage. Ergothioneine is excreted very slowly in the body, allowing it to be highly retained in tissues and erythrocytes of humans and other animals to maximise its efficacy.
In addition, it is highly stable and EGT is less prone to autoxidation at physiological pH conditions, which makes it more stable than other thiol antioxidants such as glutathione.
In the human body, energy production and other biological processes inevitably produce by-products that are highly reactive, short-lived molecules known as free radicals.
Ergothioneine also has a wide range of biological activities, it is effective in scavenging free radicals and has a variety of functions such as detoxification, maintenance of DNA biosynthesis and normal cell growth, cellular immunity, anti-radiation, whitening and anti-aging.
These free radicals may play an important role that we are not yet aware of. However, excess free radicals may cause damage to biomolecules, and this damage can lead to the development of many diseases, including neurodegeneration, cardiovascular disease, and cancer.
For medical purposes in the treatment of brain-related conditions, it can be administered to patients in various forms, such as injections, oral formulations, and eye drops, to aid in the treatment of strokes, brain dysfunction resulting from accidents, glaucoma, and other such conditions.
Since free radical damage plays an important pathological role in a wide range of diseases and ergothioneine accumulates and effectively scavenges free radicals in a wide range of body tissues, ergothioneine plays an important role in cognitive disorders, eye protection, anti-ageing, skin care, anti-cancer and cardiovascular health and treatment of other diseases.
Additionally, it can be incorporated into food and beverages, primarily targeting young individuals who are in learning or working environments. It aids these individuals in enhancing memory retention, maintaining brain health, and improving focus and work efficiency.